Titre : | Predicting menstrual bleeding patterns with levonorgestrel-releasing intrauterine systems (2021) |
Auteurs : | A.K. FRENZ, Auteur ; C. AHLERS, Auteur ; V. BECKERT, Auteur |
Type de document : | Article : Article de périodique |
Dans : | EUROPEAN JOURNAL OF CONTRACEPTION & REPRODUCTIVE HEALTH CARE (THE) (Vol. 26 - N° 1, February 2021) |
Article en page(s) : | pp.48-57 |
Langues: | Anglais |
Index. décimale : | 232 (Contraception intra-utérine) |
Résumé : |
Purpose To develop a bleeding-pattern prediction model to inform counselling on amount and regularity of bleeding after levonorgestrel-releasing intrauterine system (LNG-IUS) placement. Materials and methods Fixed-cluster and regression-tree models were developed using bleeding data pooled from two clinical trials of LNG-IUSs. Models were trained and cross-validated on LNG-IUS 12 data, then applied to LNG-IUS 20 and LNG-IUS 8 data. Three clusters were generated for the fixed-cluster model: predominantly amenorrhoea; predominantly spotting; and predominantly bleeding. A random-forest model predicted the future-bleeding cluster, then the probability of cycle regularity was calculated. In the regression-tree model, women were assigned by the model to less- or more-bleeding groups. Results With LNG-IUS 12 (n = 1351) in the fixed-cluster model, 70.4% of women were correctly classified. The correct classification rates for LNG-IUS 20 (n = 216) and LNG-IUS 8 (n = 1300) were 72.2% and 69.0%. The probability distribution for cycle regularity showed regular and irregular bleeding were best separated with LNG-IUS 12 data, and less well with LNG-IUS 20 and LNG-IUS 8 data. In the regression-tree model there was high variability in the more- and less-bleeding group distributions with LNG-IUS 12 data. Conclusions A fixed-cluster model predicted bleeding patterns better than a regression-tree model in women using LNG-IUS, yielding understandable, informative output. |
Catégories : | CONSEIL MEDICAL , CONTRACEPTION HORMONALE , CONTRACEPTION INTRA-UTERINE , DISPOSITIF INTRA-UTERIN , MENSTRUATION |
Exemplaires (1)
Code-barres | Cote | Support | Localisation | Section | Disponibilité |
---|---|---|---|---|---|
cedif°p°000805 | EUR | Périodiques | CEDIF Bruxelles | Périodiques | Consultation en salle de lecture Exclu du prêt |