| Titre : | Endometriosis-associated pain scores and biomarkers in users of the etonogestrel-releasing subdermal implant or the 52-mg levonorgestrel-releasing intrauterine system for up to 24 months (2020) |
| Auteurs : | D. MARGATHO, Auteur ; N.M. CARVALHO, Auteur ; L. BAHAMONDES, Auteur |
| Type de document : | Article : Article de périodique |
| Dans : | EUROPEAN JOURNAL OF CONTRACEPTION & REPRODUCTIVE HEALTH CARE (THE) (Vol. 25 - N° 2, April 2020) |
| Article en page(s) : | pp.133-140 |
| Langues: | Anglais |
| Index. décimale : | 314 (Affections des organes génitaux) |
| Catégories : | |
| Résumé : |
Objectives: The aims of the study were to correlate endometriosis-associated pain, evaluated by visual analogue scale (VAS) scores, with serum levels of etonogestrel (ENG), levonorgestrel (LNG), CA-125 and soluble CD23 in users of the ENG implant or the 52-mg LNG-releasing intrauterine system (52 mg LNG-IUS) for up to 2 years after device placement. Methods: A randomised trial was conducted at the University of Campinas Medical School, Brazil. All participants (n = 103) had had endometriosis-associated chronic pelvic pain or dysmenorrhoea, or both, for more than 6 months. Participants were randomly assigned to use an ENG implant (experimental treatment) or a 52-mg LNG-IUS (active comparator). Follow-up was conducted 6 monthly for up to 24 months after device placement. Dysmenorrhoea and chronic pelvic pain were evaluated using a VAS and the scores were correlated with serum levels of ENG, LNG, CA-125 and soluble CD23. Results: Both progestin-only contraceptives significantly reduced VAS scores for dysmenorrhoea and chronic pelvic pain and reduced serum levels of soluble CD23 (p 0.005). Conclusion: Both contraceptives improved dysmenorrhoea and chronic pelvic pain scores in women with endometriosis-associated pain and they reduced serum levels of soluble CD23; however, serum levels of CA-125 were reduced only in ENG implant users over the 24-month study period. |
Exemplaires (1)
| Code-barres | Cote | Support | Localisation | Section | Disponibilité | Caution pour l'emprunt |
|---|---|---|---|---|---|---|
| cedif°p°001486 | EUR | Périodiques | CEDIF Bruxelles | Périodiques | Consultation en salle de lecture Exclu du prêt |
